Indeterminacy of spatiotemporal cardiac alternans
نویسندگان
چکیده
منابع مشابه
Indeterminacy of spatiotemporal cardiac alternans.
Cardiac alternans, a beat-to-beat alternation in action potential duration (at the cellular level) or in electrocardiogram morphology (at the whole heart level), is a marker of ventricular fibrillation, a fatal heart rhythm that kills hundreds of thousands of people in the United States each year. Investigating cardiac alternans may lead to a better understanding of the mechanisms of cardiac ar...
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We investigate the dynamics of spatially discordant alternans (SDA) driven by an instability of intracellular calcium cycling using both amplitude equations [P. S. Skardal, A. Karma, and J. G. Restrepo, Phys. Rev. Lett. 108, 108103 (2012)] and ionic model simulations. We focus on the common case where the bidirectional coupling of intracellular calcium concentration and membrane voltage dynamic...
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Cellular calcium transient alternans are beat-to-beat alternations in the peak cytosolic calcium concentration exhibited by cardiac cells during rapid electrical stimulation or under pathological conditions. Calcium transient alternans promote action potential duration alternans, which have been linked to the onset of life-threatening ventricular arrhythmias. Here we use a recently developed ph...
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Amplitude equations are derived that describe the spatiotemporal dynamics of cardiac alternans during periodic pacing of one- [B. Echebarria and A. Karma, Phys. Rev. Lett. 88, 208101 (2002)] and two-dimensional homogeneous tissue and one-dimensional anatomical reentry in a ring of homogeneous tissue. These equations provide a simple physical understanding of arrhythmogenic patterns of period-do...
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We derive an equation that governs the spatiotemporal dynamics of small amplitude alternans in paced cardiac tissue. We show that a pattern-forming linear instability leads to the spontaneous formation of stationary or traveling waves whose nodes divide the tissue into regions with opposite phase of oscillation of action potential duration. This instability is important because it creates dynam...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2008
ISSN: 1539-3755,1550-2376
DOI: 10.1103/physreve.78.011902